What is wrong with suicide?

Q: What is wrong with suicide?
M: Nothing wrong, if it solves the problem. What, if it does not? Suffering caused by extraneous factors -- some painful and incurable disease, or unbearable calamity -- may provide some justification, but where wisdom and compassion are lacking, suicide cannot help. A foolish death means foolishness reborn. Besides there is the question of karma to consider. Endurance is usually
the wisest course.
Q: Must one endure suffering, however acute and hopeless?
M: Endurance is one thing and helpless agony is another. Endurance is meaningful and fruitful, while agony is useless.

(...)

Q: Is it not obligatory to live out one’s natural span of life?
M: Natural -- spontaneously -- easy -- yes. But disease and suffering are not natural. There is noble virtue in unshakable endurance of whatever comes, but there is also dignity in the refusal of meaningless torture and humiliation.